Matsayin da tsarin rigakafi a cikin haifuwa mutum ya yi yawa. Masana kimiyya sun tabbatar da cewa kimanin kashi biyar na mutanen da ke da rashin haihuwa ba tare da wata la'akari ba suna da matsala tare da tsarin tsarin. Ɗaya daga cikin abubuwan da ke hade da tsarin rigakafi, wanda zai haifar da rashin haihuwa, shine kira na jikin antispermal.
Wadannan kwayoyin suna shiga cikin tsarin hulɗar jigilar kayan aiki, ba tare da damar spermatozoa su shiga harsashin kwai ba. Hanyar da suke aikatawa ba a fahimta ba tukuna, amma an rigaya ya bayyana cewa wadannan kwayoyin cutar sun hana amsawar acrosomal na kwayoyin spermatozoon, wanda ke zama daya daga cikin abubuwan da suka dace don haɗuwa. Idan ɗaya daga cikin abokan tarayya, maza ko mata, yana da kwayoyin halitta, to, ingancin embryos yawanci ya fi muni daga mutanen da ba su da irin wannan jikin, wanda zai rage tasirin rashin kula da rashin haihuwa ta hanyar hadewar in vitro. Idan ACAT ba'a samu ba tare da nasara tare da fasaha na ra'ayin mazan jiya, hanyar da aka fi so don irin wannan nau'i shine gabatar da spermatozoa cikin kwai (ICSI).
Hanyoyi na kayyade maganin antisperm a cikin mata
A cikin wakilai na jima'i jima'i, magungunan antisperm an ƙaddara su a ƙwaƙwalwar ƙwayar mahaifa da kuma a cikin jini. Yana da mahimmancin gwaji don kasancewar irin wadannan kwayoyin cutar a cikin waɗannan ma'aurata da suke shirin IVF.
Mafi sau da yawa wajen tabbatar da maganin cututtukan antisperm, hanyoyin da aka tsara akan ƙaddamar da kwayar cutar da ake amfani da ita ga antigens membrane. Wadannan sun haɗa da hanyoyin kamar:
- Gwajin gwagwarmayar spermatozoa tare da membran mucous na cervix, ko kuma bayan aure. Dole ne a tuna cewa daya daga cikin mawuyacin abubuwan da ke tattare da jarrabawar gwaje-gwaje na rashin lafiya shine cewa akwai ACAT a cikin kwayar halitta, wato, matsalar ta shafi mutum, ba ga cervix ba. Duk da haka, sau da yawa yakan yiwu a lura da hadewar mace da namiji. Gwajin gwajin bayanan jarrabawar ba ta da tabbaci a lokacin nazarin rashin haihuwa kuma a gare shi yawan bayanai na ƙarya ba su da yawa. Wannan shine dalilin da yasa ba'a amfani da shi ba kadai, kawai tare da bayanai daga bincike kan ACAT;
- MAR-gwajin. Wannan wata hanya ce ta ba ka damar ƙayyade adadin spermatozoa wanda ke hade da kwayoyin cutar IgA da IgG, kuma yana taimakawa wajen sanin mai daukar magungunan antisperm a cikin ruwaye na halitta kamar ƙwaƙwalwar mahaifa, spermoplasm, plasma jini. An gane wannan gwaji a duniya kamar yadda aka gano ma'auni na ACAT, yana da ƙwarewa da matsayi na musamman;
- Gwajin gwagwarmaya ta ƙarshen abu ne wanda aka ƙaddamar kuma ba a gwada gwajin ACAT ba. Wannan gwajin shine hanyar da ta dace don gane ACAT a cikin ruwaye na halittu, irin su plasma jini, maniyyi, ƙwararren mahaifa. Yana da karfin gaske. Saitin kwayoyin da za a iya gano ta hanyar amfani da wannan hanya baya saba daidai da saitin kwayoyin cutar da gwaje-gwaje biyu da suka gabata, saboda haka ana haɗuwa da su don samun ƙarin abin dogara;
- ELISA (immunoassay enzyme) - an fi amfani da ita don bincika ACAT a cikin jini jini. Anyi la'akari da ɗaya daga cikin ƙarin hanyoyin don bincikar ACAT. Hanyoyin manyan ACAT, waɗanda aka ƙaddara ta wannan hanyar a cikin jini a cikin jini a cikin mata, bazai haɗu da lalacewa a farkon lokacin ciki.
Hanyar magani
Matakan ma'aurata da aka gano tare da ƙara yawan ACAT za a iya yin su ta hanyoyi daban-daban, dangane da sakamakon binciken. Na farko, a mafi yawancin lokuta, ana amfani da hanyar shamaki, wato, kwaroron roba, tare da yin amfani dashi na tsawon watanni 2-5 ko a cikin yanayi mai rikitarwa, lokacin da ba'a amfani da robaron roba ba fãce a kwanakin da suka dace da bayyanar ciki.
Rage yawan maniyyi da ke shiga cikin jikin mace yana haifar da raguwa cikin kira na kwayoyin cuta kuma yana kara yawan sauƙin ciki.
Bugu da ƙari, za a iya ba da magani, wanda zai rage danko da ƙwayar magunguna kuma ya hana kira ACAT a cikin ma'aurata. Idan hanyoyi masu rikitarwa ba su taimaka ba, to sai su matsa zuwa ISKI.